Insights on the Pathophysiology of the Progression to Decompensated Hepato-Splenic Schistosomiasis

Hepato-splenic schistosomiasis is the most important etiology of non-cirrhotic portal hypertension. It represents a particular type chronic liver disease, which presents unique characteristics that differentiate it from those found in cirrhosis. The relative preservation parenchyma despite fibrosis was thought to yield more benign course hepato-splenic terms synthetic dysfunction and late decompensations. However, wide range immunologic vascular modifications responsible for an otherwise progressive disease resulting decompensated condition frequently undistinguished hepatic A predominant Th2 immune response type, fibrogenic profile cytokines interleukins such as IL-13, provides immune-inflammatory background favors its progression. Intra-hepatic changes with vein branch derangement abnormal proliferation also contribute continued disarray architecture This article will review pathophysiological aspects might explain progression severity.